Posts Tagged ‘growth hormone deficiency’

Growth Hormone Deficiency

Wednesday, August 31st, 2011 by by

Growth Hormone Deficiency (GHD) is generally due to the pituitary gland being unable to produce sufficient GH to generate the growth process. GHD does not affect intrauterine growth, at least to an extent measurable by birth weight or length, but from the second year of life growth is slower than normal, and occasionally growth failure commences from birth. Most cases of growth hormone deficiency are idiopathic, meaning of unknown origin. Idiopathic growth hormone deficiency occurs, it seems, in about 1 in 3800 births.

We met with Haven’s Endocrine doctor on June 20th and discussed Haven’s need for growth hormone.  She has stayed in the 5th percentile since Hi CY. We decided we would check the levels and see where she is.  We received an email that Haven is at a level 71.  A normal IGF-1 level would be around 250 or so – with a very low at an 88.  Normally, a child grows about 2 inches per year. A child with growth hormone deficiency usually has a growth pattern of less than 2 inches per year. In many cases, the child grows normally until he or she is about 2 or 3 years old; then, signs of growth delay begin to show.  We were told that Haven will need to grow 2 inches by December in order to not be put on the GH treatment.

Haven may have to do a stimulation test before treatment.  What is this?

  • GH stimulation tests help to diagnose GH deficiency and hypopituitarism. For a stimulation test, a sample of blood is drawn after 10-12 hours of fasting. Then, under close medical supervision, a person is given an intravenous solution of insulin or arginine. Blood samples are then drawn at timed intervals, and GH levels are tested in each to see if the pituitary gland was stimulated by the insulin (or arginine) to produce expected levels of GH. Other GH stimulants include clonidine and glucagon.

Treatment? (more…)

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Endocrine Visit – June 20

Wednesday, June 22nd, 2011 by by
On June 20th, we took Haven in to meet with her Endocrine doctor – he was the doctor that saved her life by finding her cancer and diagnosing her with ROHHAD Syndrome.  My main concerns have been Haven’s weight to height ratio and the fact that I knew she hadn’t grown much over the past year.  I had a few emails back and forth with him over the six months we hadn’t seen him.

Haven has maintained her 80 lbs since January 2009.  Her Hi CY treatment for ROHHAD stopped her weight gain and her stealing of food.  Immediately following Hi CY, Haven jumped up about 3 inches in height – this was a make up from the year on steroids (which stop growth) – but since that initial jump, Haven hasn’t done much.

So our main discussion with him was regarding her growth and if she is deficient.  Growth Hormone Deficiency is a disorder that involves the pituitary gland, which produces growth hormone and other hormones.  Growth hormone is necessary for normal growth and development in children.  Haven’s last IGF-1 test was done in May while in Oncology.  This came back low. (more…)