Yes, with both. I cried during Caleb's labor once the pitocin started making my contractions harder and stronger, but then I got the epi at 4 cm and all was peachy.
With my second son Lucas, as soon as I hit 6 cm the pain became unbearable and I cried the whole time (along with yelling and swearing, LOL). I still managed to go natural without any pain meds, though, so every tear was worth it. And of course I cried happy tears when they handed him to me!