I am Homozygous for the A1298C, I only required a baby aspirin. And the one thing that was not mentionted. If you have elevated homosystine levels, YOU are at higher risk for blood clots with the MTHFR mutation.
Below is some great links that I had saved after I was told I had it. Yes you have an issue, yes it is GREAT!, it is HORRIABLE!, Yes it is TREATABLE! When I got told we have a problem it was after three loss... I was happy, pissed, ANGRY! I lossed three babies... and a baby aspirin... a baby aspirin was all I needed? ARE YOU KIDDING ME! I hope this is it for you! I pray that you will have your rainbow baby(ies) in your arms soon!
With MTHFR, there are two different genes identified for this mutation, and it's possible to be "heterozygous," "compound heterozygous," or "homozygous." The MTHFR gene mutation has varying degrees of possible implications. The order of potential severity from most to least is:
1. C677T & C677T (Two C Copies - C677T Homozygous)
2. C677T & A1298C (One Copy of Each The C & A - Compound Heterozygous)
3. C677T (One C Copy - C677T Heterozygous)
4. A1298C & A1298C (Two A Copies - A1298C Homozygous)
5. A1298C (One A Copy - A1298C Heterozygous)
The MTHFR mutation is fairly common in the general population. Approximately 44% of the population is heterozygous and another approximate 12% are homozygous for the MTHFR mutation. Compound heterozygous and homozygous MTHFR have the highest incidences of being linked to implantation failure, late term miscarriages, specific birth defects and overall vascular health. Whichever type of MTHFR you have, it should not be discounted, particularly if there is a personal or family history of any such incidences.
What Are the Implications?
Any and all of the mutations can affect homocysteine levels, but there is much dispute as to whether elevated homocysteine levels are actually needed in order for MTHFR to cause medical complications. Many other MTHFR patients have normal homocysteine levels; yet have had implantation problems, miscarriages, and/or stillbirth(s) due to clotting problems. So it is important to find out what your Homocysteine levels are (although again, normal doesn't necessarily mean all is well). This is a serious field and MTHFR is a serious condition, so consulting an expert is wise. Research shows that high homocysteine levels and/or those with the mutation show a higher propensity for thrombosis (blood clots), arteriosclerosis (hardening of arteries), Alzheimer's, stroke, heart attack, Fibromyalgia, migraines (especially with "Aura" migraines), osteoporotic fractures, bone marrow disorders and for those of child bearing years, it has found to be connected to higher incidences of down's syndrome, spina bifida, other neural tube defects, trisomy, miscarriage, stillbirth, implantation failure, placental abruption, preeclampsia, higher incidences of autism, amongst others. Additionally, if you test positive you may want to have your parents, siblings, and any children you may already have tested, as well.
There are a few positives to this disorder. Because folate is necessary for cellular division, there is support that shows having this disorder can actually help keep certain types of cancer cells from multiplying as rapidly, so there are some benefits from having this mutation.
Here are some links I go to look up info...
MTHFR - Methylene-Tetra-Hydro-Folate-Reductase | BabyMed.com
MTHFR as a Miscarriage Cause - Why Doctors Disagree Over Testing for MTHFR in Recurrent Miscarriages
ObGyn/Pregnancy issues: MTHFR, factor v leiden, heparin therapy
MTHFR - Symptoms, Treatments and Resources for MTHFR
MTHFR
MTHFR Forum
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Dr just called me himself with my blood work from last week...
...I don't know a lot about it, so hopefully others can be more help.
04/21/10 - 7w5d 
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I hope that you can get it all figured out so that you will get your rainbow baby soon 
and 2-4-2012, chemical 
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