Yes, and know that if affects everyone differently. I personally HATED it. First off, I felt sick to my stomach on it for the whole 2 months I was on it. Just slightly, so it was not that bad. Still, I hate feeling queasy.
Also, I was told that I would not gain any weight on it. I gained 30lbs in 2 months!

I have never had issues with gaining weight before, and I am still trying to get those last 15lbs off (This was over a year ago). My doctor actually argued with me saying that I should have not gained any weight and that it had to be something else. Well seeing how had been the same weight for years, I seriously doubt that it was "something else." I even dieted and exercised the whole time. I also developed acne, even though it helps acne for others.
Well, like I said, some people do great on it, others not so much. I was one of the unfortunate ones.