For me I start taking them on CD9 or 10. I have very irregular cycles so I never know I will O. They say not to take them early in the morning because they can pick up the HCG from the day before. I've heard not to keep testing after a + but I keep doing it because some months you can get a surge and not really O yet due to stress or other facts.
www.peeonastick.com is a very good site to check out. I know I probably made things more confusing but I do have to say that I have gotten a + OPk one day and - the next day and still Oed that day of the +. Some months you may get more then 1 + OPK's in a row and other months you may only get 1. Check out that site and maybe that will help you more. Good luck