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I am 33yrs old and almost 17 weeks pregnant with my 2nd child (I have a healthy & beautiful almost 3yr old daughter). After having the quad screen done and having "abnormal/postive" results for possible DS with my daughter I told myself that I would not take that test again. After waiting 1 1/2 months to have a Level II ultrasound we were told there were no soft markers for DS and that an amnio an option, but not recommended. We opted out of doing the amnio. Needless to say I ended up having the quad screen done again with this preganancy and received a call from my OB that it came back "abnormal/postive" again. She told me that this time, my odds of DS are 1:10. With my daughter the odds were something like 1:80. I can't get in to have the Level II ultrasound until 12/02 and I am scheduled to have an amnio done right after the ultrasound. I have been reading these posts and any other posts I can find on every possible site to try to find some comfort. I was able to speak to an RN at the maternal/fetal medicine center I am going to on 12/02 and she said that she sees numbers like this all of the time and mostly the babies end up being totally healthy. I am terrifed and feel like I am going to have a nervous breakdown. My close friends and family keep telling me not to worry b/c I already had the false positive with my first pregnancy but nobody really knows what kind of torture this is, I keep breaking down into tears and I have next to no patience with my poor daughter. Has anyone been told they have 1:10 odds of DS from the quad screen and found out that everything is fine and healthy?