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It depends on how sensitive the test is - there is a sticky post on the TTC forum that outlines the sensitivity of HPT's. Also it takes time - some women show + as early as 10 DPO, but other don't show up until AF is late and others even longer. On rare occasions some women never show positive on an HPT, but are pregnant. I would give it a couple of more days and take another test - get a sensitive "early" test. If it is still negative and no AF, then see your doctor about a blood test.
Edited to add - I do remember a while back someone asked some of the ladies on the DDC's how long it took them to get the BFP and a few said it wasn't until AF was a week late.