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Recurrent M/c


Forum: Recurrent Miscarriage and Pregnancy Loss

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  #1  
June 28th, 2011, 01:35 PM
cavewoman's Avatar our miracle is here!! <3
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Pretty recently we had our 4th m/c. The first 3 were chemical pregnancies and the 4th I had bleeding start at 9w5d but doctors seem to think growth stopped more at like 7 weeks. I had a non diagnostic u/s done at 6w5d and a heartbeat was detected. The lovely military doctors lied to my face at my u/s to confirm the loss at "10 weeks" and said no testing could be done on the tissue except to confirm whether it was actually fetal tissue I guess? I was too upset to fight it and just let it go. The tiny sample they took (which mind you was done after I had passed clots for 2-3 days) came back as not having been fetal tissue though we saw shreds on the u/s. I'm sorry if I'm too graphic in my description I just don't know any other way to describe it. Anyway, I finally got my referral to see an RE and the RE said I have a little more blood testing to be done and wants to do a hysteroscopy. He seems to think that because we've had 4 losses in a years time its likely an egg quality issue. He said the chances of finding something thru the remaining testing is less than 5% and if nothing is found, he is recommending IVF so they can weed out the "bad eggs." Does this sound right to anyone? It seems so drastic to me. I mean, I always thought IVF was for those who weren't able to become pregnant on their own at all? He told me to be careful and avoid pregnancy because I am set up for failure as it stands until we know the cause.
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  #2  
June 28th, 2011, 01:52 PM
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Do you know what testing has already been done?
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  #3  
June 28th, 2011, 02:06 PM
plan4fate's Avatar I may bend, but not break
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I'd request to have testing done from the beginning, even if it's already been done before. With out intensive testing they cannot determine an egg quality issue, sounds like the RE wants to skip all the steps and jump to the expensive part.

and yeah, all sorts of fetal testing can be done at 10 weeks if you have a D&C. It's much harder after you've started passing clots, since the uterine walls does shed as well and won't contain any fetal tissue.

HUGS. sounds like you've got a bunch of idiot doctors.
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  #4  
June 29th, 2011, 08:00 AM
cavewoman's Avatar our miracle is here!! <3
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Looks like what was done is:
TSH
ABO & Rh
Rubella
Chromosome Analysis
Hepatitis B Surface Antigen HbSAg
RPR/VDRI

and whats left to do is:
FSH
Estradiol Level E2
Prolactin
ATA & AMA/TPO
APA
ASA
Chlamydia Antibody
HCV
HIV
HTLV

and then the Cervical cultures & Hysteroscopy

And they've already done semen analysis and I believe a chromosome analysis on DH as well - not sure if they did the Hepatitis, RPR/VDRI, HIV & HTLV on Dh yet though - need to get the copy of his testing for the doc to know.

Ugh.. I had a feeling thats all it is was him wanting to skip to the expensive stuff ;\ I can probably have them re-do the bloodwork that was already done no problem though when I get the others done. I also planned to see another fertility place thats unfortunately military related of some sort in another city before jumping to anything big.
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  #5  
June 29th, 2011, 08:03 AM
esparando para bebé's Avatar Proud Car Seat Technician
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*hugs* I agree with Ashley. I also agree with your RE about waiting to ttc though. Most causes are easily fixed. If you can find your cause you can likely work to fix it and not have another loss.
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  #6  
June 29th, 2011, 08:07 AM
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I am so sorry
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  #7  
June 29th, 2011, 09:47 AM
LisaB's Avatar Mom to twins + 1
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I had 4 minscarriages too before moving to IVF. We had a lot of REs working with us at our clinic, and I've done a lot of research on the subject, so I can say with some conviction that IVF is NOT just for people who can't get pregnant. On the contrary, you stand a much better chance of having a live birth with IVF with your history than someone who can't conceive at all.

It does sound like an egg quality issue. PGD (which you can only do with IVF) is perfect for you. I'm glad they'll do some additional testing, but don't feel bad that no placental study was done (a karyotype) because they would likely only have confirmed what they already suspect, chromosomal abnormalities. It's really the only thing left since they've already ruled out most immunity issues with the bloodwork.

I had a successful IVF after 4 miscarriages. I did PGD to weed out the bad embryos. Of the 8 embryos tested, 4 were deemed "good" and of those 4 only three continued to grow. The only problem with PGD is that its's invasive and sometimes hurts the embryo so that it no longer continues to grow. That small risk is well worth the benefits, though, in my opinion, because without it you wouldn't know which ones to transfer. We transferred three and ALL THREE implanted successfully (long story, we ended up with only twins in the end) but you can see how effective PGD can be. I recommend transferring only as many babies as you're prepared to have safely, and watch out for splitting, it can happen (it happened with us so we had quads at one point).

Other things you can do to improve egg quality:

1. stop drinking completely (even a little can affect egg quality - I was told to stop drinking 4 months prior to my IVF);

2. go on a diabetic diet to stabilize blood sugar levels, which can calm your immune system. The theory is that anti-ovarian antibodies can cause poor egg quality (note this is beyond the scope of REs, only a reproductive immunologist would be aware of this, as REs do not test for AOAs). There are other ways to stop an abnormal immune response, such as taking steroids or doing IVIg, but a diabetic diet is a much healthier, less drastic and safer alternative.

3. you could also try acupuncture, some people think this helps calm your immune system too. Some studies show acupuncture is beneficial to IVF.

4. There is also a procedure called lymphocyte immune therapy, but it's drastic in the sense you have to jump through a lot of hoops to have it done, though the procedure itself is no big deal (basically just a blood draw and a shot). However there is no real proof that it works. I had it done, my IVF was successful, and I had a totally unplanned pregnancy after my IVF after my very first menstrual cycle following my previous pregnancy. But I can't say for certain the LIT is the reason for these things.

5. Take 1 baby aspirin daily and extra folic acid.

Good luck!!
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Last edited by LisaB; June 29th, 2011 at 09:53 AM.
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  #8  
June 29th, 2011, 10:01 AM
cavewoman's Avatar our miracle is here!! <3
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Thank you so much for your response Lisa! I will look into all that was mentioned Not sure where Carmel CA but I'm also in CA - in 29 Palms.. the middle of the desert. I had to drive to Torrance to see my RE and may be looking into a facility in San Diego if we end up going the IVF route.
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  #9  
June 29th, 2011, 10:30 AM
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I don't think you had the whole thrombophilia panel done, might be something to ask about.
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  #10  
June 29th, 2011, 03:08 PM
geogeek's Avatar Marsi's Mommy
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I attribute my pregnancy sticking to baby aspirin. I took it for 2 months before I got pregnant with this little one. It made my cycle better, I didn't have clotting during AF. It is something non-invasive that can be done along with the other tests. I hope that you get your little rainbow baby soon!
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  #11  
June 29th, 2011, 03:22 PM
cavewoman's Avatar our miracle is here!! <3
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Quote:
Originally Posted by geogeek View Post
I attribute my pregnancy sticking to baby aspirin. I took it for 2 months before I got pregnant with this little one. It made my cycle better, I didn't have clotting during AF. It is something non-invasive that can be done along with the other tests. I hope that you get your little rainbow baby soon!
I was on 81mg daily during this last pregnancy (all cycle even) and progesterone 200mg nightly ;\
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  #12  
June 30th, 2011, 12:57 AM
LisaB's Avatar Mom to twins + 1
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Hi Bonnie, I'm about 3 hours south of San Francisco (next to Monterey). Our IVF clinic was up in Fremont, because it was the only one with an opening. I love the San Diego area, we have family there & visit often!
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  #13  
June 30th, 2011, 05:51 PM
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I am so sorry you have gone through 4 losses. That is so hard. I hope that you can get some answers and have a beautiful rainbow baby.

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  #14  
June 30th, 2011, 07:29 PM
kaylakay's Avatar Love Being A Mommy
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I would for sure ask for ALL blood tests before going over to IVF.

If they do find an answer sometimes it can be easily fixed.

Yes, IVF is expensive and drastic... but to me... if they could solve my recurrent miscarriage with that I would TOTALLY do that.

I currently am trying to get my insulin down and they will start me on progesterone 3 DPO, baby aspirin and maybe Heparin or Lovenox because I had a very small abnormality on my blood clotting tests... So I would for sure get those tested.


Good luck and please keep us updated!!!!!

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  #15  
June 30th, 2011, 07:33 PM
MauMama's Avatar formerly La_Sirena
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I am so sorry for your losses. I had 4 miscarriages before my daughter was born. I've since had 3 losses including twins in 07. I had a miscarriage earlier this year.

We wanted to do PGD and went to the REs here who said that the govt doesn't allow it due to the fear of designer babies. Such ignorance in NZ! I think you need to get a really great blood panel done by people who know and get it all.

PGD has given SO many of fellow infertile friends babies. I can count about 6 who have babies today because of PGD giving them 'great' embryoes.

My losses are put down to autoimmune issues. My daughter's birth is pure luck for us. But, it does show, that it CAN happen.

So, to your list, I'd add:

ANA
Rheumatoid Factor
testing for antiphospholipid antibodies
CRP
ESR
Insulin Resistance
blood insulin testing
Testosterone levels
Celiac blood test
Thyroid testing T3, T4
And as many clotting panels as you can get.

Lots of luck to you.
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