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3rd miscarriage


Forum: Recurrent Miscarriage and Pregnancy Loss

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  #1  
August 14th, 2006, 09:07 AM
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Join Date: Aug 2006
Posts: 4
I am new to this website and I was hoping someone out there might be able to help me. I recently found out I have miscarried. This is my third time in 2 years that I have miscarried. All three have happened at the 7 week mark. First one was 7w 5d, Second was 7w 4d, and this one was 7w 6d.

After my second one I was sent to a specialist and they noticed that my body was producing an antibody that stops the babies heart. It is the same antibody that is found in most patients with Lupus, but I do not have Lupus. Because of this they suggested that I take baby aspirin, and folic acid, which I did, but it didn't work. This last time we went in at the 6 week mark and we heard a very healthly heartbeat, but then a week later, we couldn't hear anything. I have no problems getting pregnant, it is just keeping the baby past 7 weeks.

My question is has anyone ever had a similar situation, and if so can you give me suggestions. I am seeing my doctor on Wednesday and I was going to see if she would refer me to a specialist.
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  #2  
August 14th, 2006, 09:31 AM
EricaInOhio's Avatar Veteran
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Can you tell me which antibody it was? I am a research scientist and have read up a lot on phospholipid antibody disorders recently, but not much on the others. Since you mentioned Lupus I'm guessing it is either anticardiolipin or lupus anticoagulant. It is important to ask which it was, what your level was, and what is considered normal. My levels of anticardiolipin came back "indeterminant". An irresponsible nurse told me it was elevated, so then I spent a week researching the condition before I knew the true result. With antibody screens they are prone to false positive so they don't give much credit to a weakly positive screen like mine. My doc doesn't think that's the cause of my m/c's. However, if my level had been higher they would consider me to have the disorder, which causing blood clotting in mom and umbilical veins (baby) as well as attacking the placenta. I'm taking a baby aspirin in case, but someone with higher levels would need to be placed on a much stronger blood thinner. This may not pertain to your case depending on what antibody it is that is elevated. The biggest thing is you need to find out how elevated your levels were because that can determine how likely this is to be causing the m/c's and what treatment is appropriate. There is at least 1 woman in the high risk pregnancy board with Lupus. She might be able to offer some insight. If your levels are high enough to be a true positive I would suggest asking for a referral to a hematologist as well as a consult with a high risk OB/GYN. Try not to freak out yet. All of us here are looking for answers and unfortunately with these blood tests things are not always what they seem. Feel free to PM me if I can help in any way. I'm not a medical doctor, but I do understand the science behind this stuff and have access to all the medical journals. Good luck!
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  #4  
August 14th, 2006, 03:20 PM
beck12's Avatar Platinum Supermommy
Join Date: Jul 2005
Location: Michigan
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Sweetie I am so sorry for your losses. It is so confusing to get info & not have everything explained thoroughly & then even worse to mc again. I also don't know a whole lot about lupus. I wanted to ask though if you have had all hte other testing done as well. For your losses to be so similar is gestational age, it couls also point to a genetic/chromosomal issue. In my case, Dh has a chromosomal abnormality, which was initially overlooked because my mc's didn't happen near the same gestational age..but I see yours were quite close. I don't knwo if that is helpful at all - I just want to be sure they are looking at everything for you instead of taking one test, having a "funny" level & calling that good enough & quit looking. I also hope perhaps someone here with more experience in that area might be able to shed some light.

I wish you all the best & again I am so sorry for your loss.
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We've begun to raise daughters more like sons... but few have the courage to raise our sons more like our daughters. ~Gloria Steinem

If a man has been his mother's undisputed darling he retains throughout life the triumphant feeling, the confidence in success, which not seldom brings actual success along with it. ~Sigmund Freud
My mom is a neverending song in my heart of comfort, happiness, and being. I may sometimes forget the words but I always remember the tune. ~Graycie Harmon
Don't wait to make your son a great man - make him a great boy. ~Author Unknown
You don't raise heroes, you raise sons. And if you treat them like sons, they'll turn out to be heroes, even if it's just in your own eyes. ~Walter M. Schirra, Sr.
A man loves his sweetheart the most, his wife the best, but his mother the longest. ~Irish Proverb
Mother's love is peace. It need not be acquired, it need not be deserved. ~Erich Fromm
Children need love, especially when they do not deserve it. - Harold Hulbert
Mother is the name for God in the lips and hearts of little children. ~William Makepeace Thackeray
God could not be everywhere, so he created mothers. ~Jewish Proverb
The best conversations with mothers always take place in silence, when only the heart speaks. ~Carrie Latet




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  #5  
August 14th, 2006, 04:00 PM
srs srs is offline
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I'm so sorry for your losses. I have lost two at similar gestational ages (7w4d and 6w6d), and I had one antibody test level come back abnormal, but a verification test came back normal, so unfortunately I don't have any answers either.
At this point I would think you would definitely be referred to a specialist. Best of luck to you, and welcome to the board.


Sara
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  #6  
August 14th, 2006, 05:44 PM
4iris's Avatar Platinum Supermommy
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I'm so sorry for your losses. I have nothing helpful to add to your question, but wanted to welcome you to the board. I hope you find peace and friendship here.
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  #7  
August 14th, 2006, 08:08 PM
Regular
Join Date: Aug 2006
Posts: 4
Quote:
Can you tell me which antibody it was? I am a research scientist and have read up a lot on phospholipid antibody disorders recently, but not much on the others. Since you mentioned Lupus I'm guessing it is either anticardiolipin or lupus anticoagulant. It is important to ask which it was, what your level was, and what is considered normal. My levels of anticardiolipin came back "indeterminant". An irresponsible nurse told me it was elevated, so then I spent a week researching the condition before I knew the true result. With antibody screens they are prone to false positive so they don't give much credit to a weakly positive screen like mine. My doc doesn't think that's the cause of my m/c's. However, if my level had been higher they would consider me to have the disorder, which causing blood clotting in mom and umbilical veins (baby) as well as attacking the placenta. I'm taking a baby aspirin in case, but someone with higher levels would need to be placed on a much stronger blood thinner. This may not pertain to your case depending on what antibody it is that is elevated. The biggest thing is you need to find out how elevated your levels were because that can determine how likely this is to be causing the m/c's and what treatment is appropriate. There is at least 1 woman in the high risk pregnancy board with Lupus. She might be able to offer some insight. If your levels are high enough to be a true positive I would suggest asking for a referral to a hematologist as well as a consult with a high risk OB/GYN. Try not to freak out yet. All of us here are looking for answers and unfortunately with these blood tests things are not always what they seem. Feel free to PM me if I can help in any way. I'm not a medical doctor, but I do understand the science behind this stuff and have access to all the medical journals. Good luck![/b]
The test they did was the Lupus Anticoagulant panel, and my came back as a 46 f for the SSB (La) antibody, which technically inconclusive but they thought maybe that is what was causing it since 50 f is positive. I did read a little bit about this antibody, but i haven't really found anything on it that relates to me, at lease as far as symptoms go.
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  #8  
August 15th, 2006, 09:44 AM
EricaInOhio's Avatar Veteran
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You have probably already read that a positive Lupus anticoagulant and anticardiolipin are grouped together into a class of auto-immune disorders known as antiphospholipid syndrome (APS). You can find a lot of information online by searching for the syndrome above. They are treated similarly with blood thinners and sometimes steroids (but steroids comes with added risks). I'm still searching for specific info on Pubmed about the antibody you listed. I'll let you know if I dig up anything interesting. I'm considering going to a hemotologist with my boarderline anticardiolipin value even though my OB doesn't think it causes problems until values are in the high positive range. It can't hurt to get a second opinion, so I just may do that. If your doc thinks your values could be to blame then I expect he/she will refer you to a hemotologist as well.

Here's a site you might check out http://www.thedoctorsdoctor.com/diseases/a...id_antibody.htm
Good luck and keep us posted!
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Are you aware of the benefits of babywearing? Visit me at www.carrymemama.com to learn more. "BABIES, BORN TO BE WORN!"



Part time Micro prof., full-time breastfeeding, cloth diapering, babywearing WAHM of 2.
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  #9  
August 15th, 2006, 03:56 PM
beck12's Avatar Platinum Supermommy
Join Date: Jul 2005
Location: Michigan
Posts: 12,330
Quote:
You have probably already read that a positive Lupus anticoagulant and anticardiolipin are grouped together into a class of auto-immune disorders known as antiphospholipid syndrome (APS). You can find a lot of information online by searching for the syndrome above. They are treated similarly with blood thinners and sometimes steroids (but steroids comes with added risks). I'm still searching for specific info on Pubmed about the antibody you listed. I'll let you know if I dig up anything interesting. I'm considering going to a hemotologist with my boarderline anticardiolipin value even though my OB doesn't think it causes problems until values are in the high positive range. It can't hurt to get a second opinion, so I just may do that. If your doc thinks your values could be to blame then I expect he/she will refer you to a hemotologist as well.

Here's a site you might check out http://www.thedoctorsdoctor.com/diseases/a...id_antibody.htm
Good luck and keep us posted![/b]
Erica - could you post that link in the sticky above & put what it relates too - that way we can keep good info available at hte top for all who read here. Thanks!
__________________
B - Crazy momma to my two boys
We've begun to raise daughters more like sons... but few have the courage to raise our sons more like our daughters. ~Gloria Steinem

If a man has been his mother's undisputed darling he retains throughout life the triumphant feeling, the confidence in success, which not seldom brings actual success along with it. ~Sigmund Freud
My mom is a neverending song in my heart of comfort, happiness, and being. I may sometimes forget the words but I always remember the tune. ~Graycie Harmon
Don't wait to make your son a great man - make him a great boy. ~Author Unknown
You don't raise heroes, you raise sons. And if you treat them like sons, they'll turn out to be heroes, even if it's just in your own eyes. ~Walter M. Schirra, Sr.
A man loves his sweetheart the most, his wife the best, but his mother the longest. ~Irish Proverb
Mother's love is peace. It need not be acquired, it need not be deserved. ~Erich Fromm
Children need love, especially when they do not deserve it. - Harold Hulbert
Mother is the name for God in the lips and hearts of little children. ~William Makepeace Thackeray
God could not be everywhere, so he created mothers. ~Jewish Proverb
The best conversations with mothers always take place in silence, when only the heart speaks. ~Carrie Latet




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