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Interesting article I found


Forum: Recurrent Miscarriage and Pregnancy Loss

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  #1  
September 20th, 2006, 02:54 AM
Mega Super Mommy
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I just wanted to edit this to add that the original post was over a year ago. I don't want anyone to get confused by the statements in the first few responses. Thank you Laura for bumping it.


BBC article

I discovered this article while I was doing a little late night surfing and thought it was interesting.




Boy babies raise miscarriage risk

By Caroline Ryan
BBC News, Prague



Boys seem more likely to trigger the immune system
Giving birth to a boy can increase the risk some women will have recurrent miscarriages, researchers have found.
University College Hospital Copenhagen looked at over 300 women who had had a healthy child, but then miscarried in their next three pregnancies.

They found those whose first baby was a boy had a third of the chance of having another baby as those who had a girl.

A boy seems to trigger an unnatural immune response in some women, they told a European fertility conference.

Pregnancies often fail because a fetus would not survive, perhaps because it has a chromosomal abnormality.


Dr Henrietta Svarre Nielsen

If a woman has three miscarriages in a row, she is referred to a specialist for help.

One per cent of all women experience such recurrent miscarriages - and a third of those have already had a baby.

These women presume they do not have a problem becoming pregnant, and seek to have another baby.

Shock to the system

The team at the Copenhagen clinic looked at 305 women who already had a child.

One hundred and eighty four - 60% of them had had boys.

The usual rate in a population would be 51%.

The researchers calculated women whose first child was a boy had a third of the chance as those who had had a girl of having a second baby, even after treatment.

And those women who do have second babies are more likely to have girls.

Clue

Dr Henrietta Svarre Nielsen, who led the research, said: "It is known that when a female carries a male, it is strange to her immune system.

"And up to 22 years later, you can pick up cells in her immune system which act against males.

"Carrying a male baby is normally tolerated - but in some cases, that obviously goes wrong."

She said her research was at an early stage, so had not identified what the problem might be.

But Dr Svarre Nielsen said it might be that the womanżs body has an unusual immune reaction to the presence of male cells, which then worsens so it is triggered even by being pregnant.

She added: "The fact that we can now detect a defect might give us a clue to what happens in a normal pregnancy."
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  #2  
September 20th, 2006, 07:45 AM
4iris's Avatar Platinum Supermommy
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Oh wow! Interesting article. Fits my situation pretty closely. Now I really can't wait to find out if doc's right about this one being a girl...
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  #3  
September 20th, 2006, 07:53 AM
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That is interesting. Fits me as well. I wonder if that means that this one will be a girl??
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  #4  
September 20th, 2006, 12:33 PM
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I had a boy the second time. I'm not normal though.
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  #5  
September 20th, 2006, 03:31 PM
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Very interesting. Almost makes me hope that my little one is a girl! I really don't need yet another reason to have a mc.
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  #6  
January 13th, 2008, 05:36 PM
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bump for R!
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  #7  
January 13th, 2008, 06:32 PM
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oh wow, i didn't see this before, and when i was reading who was posting what they were posting, i was a little confused.
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  #8  
January 13th, 2008, 09:49 PM
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Great article! Thanks for posting!

I remember reading somewhere that boys are more likely to have chromosomal abnormalities because they lack the "back-up" genes that girls have (as we are XX). So that might be another reason they miscarry more. It's probably just coincidence but with our PGD results were in line with that. Most of our embryos were boys, but in the end the only "good" embryos were 2 girls, 2 boys, and even one of those boys stopped developing, and the other developed more slowly than the girls.
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  #9  
January 14th, 2008, 07:44 AM
4iris's Avatar Platinum Supermommy
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Wow, what fun to go back and read this. So much for getting my girl!
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  #10  
January 14th, 2008, 08:25 AM
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Stumbled to that some time ago, but not felt brave enough to post it. More I read the more open questions I have found, especially in immunology. Hope doctors will find some answers and remedies soon! I know some ladies who have boys and now have problems with mcs , but as baby kariotyping is not regularly performed here and chromosomal abnormalities are the most probable reason for mc I do not want to disturb them with this info.
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  #11  
January 14th, 2008, 03:23 PM
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thanks for bumping this up - I was really interested to read it after chat the other night
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