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IUI with 5 mature follicles


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  • 4 Post By kayakr
  • 1 Post By smsturner
  • 2 Post By LindseyandJoeinAL

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  #1  
April 1st, 2013, 01:33 PM
LindseyandJoeinAL's Avatar Mega Super Mommy
Join Date: Aug 2009
Posts: 1,612
I am 37, will be 38 in August. My history: stage 1-2 endo diagnosed and removed in December 2012. Approximately 2.5 (combined) years of trying naturally with no BFP. Two IVF cycles with one daughter. Two failed FET cycles. I'm about to have my first ever IUI this week and I have 5 mature follicles with an estrogen level of 1375. We have great sperm and my hormone levels, tubes, lining, etc. are all normal/good.

Should I be concerned about having an IUI with so many follicles? My RE originally told me he was comfortable proceeding with as many as 4 for someone with my history. He said today the 5th follicle is likely to catch up and that will be okay. He gives me a high teen success rate of getting pregnant with one baby.

Please share your thoughts. Thanks!!
__________________
Lindsey - 38
Joe - 46
TTC baby #2

lap surgery Apr 2010 stage 2 endo removed
IVF #1 BFN 11/2010
IVF #2 BFP! 12/2010
Wonderful, sweet daughter Khloe born August 2011
FET #1 - Oct 2012 BFN
FET #2 - Dec 2012 BFN
2nd lap surgery Dec 2012 stage 1 endo removed
IUI Apr 2013 cancelled due to producing 10 mature follicles
IUI June 2013 BFN
IVF #3 Sept 2013 BFN
IVF #4 Nov 2013 BFP! on 8dp3dt
Expecting boy/girl twins 8/1/14


Last edited by LindseyandJoeinAL; April 1st, 2013 at 01:34 PM. Reason: mistake on a date
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  #2  
April 1st, 2013, 06:27 PM
*JenJen*'s Avatar impatiently waiting
Join Date: Aug 2008
Location: west, but east. south, but not north.
Posts: 7,690
I'd do it. My RE normally only would do an IUI with up to 4 folliciles, but would allow more in cases of patients that were not 1st timers- people who had done IVF, or had done multiple IUIs with no success, etc.
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My Blog
2006-2013 6+ years of NTNP, TTC, TTCMA, Losses, Surgeries, and Diagnoses.
RPL and Genetic Tests came back 100% normal | Endo, PCOS, severe MFI
Multiple early losses between 3 and 8 weeks.

Broken in heart, mind, and body. On a break until Summer 2014






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  #3  
April 1st, 2013, 06:29 PM
kayakr's Avatar Persuaded by POAS’ers
Join Date: May 2011
Location: Midwest
Posts: 3,620
I'd do it too! Don't waste those good follies! Do it!
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Gretchen
Me (43) DH(33) 12 years together - ttc our first together-I have 14yr old DS
Cycles 1-6 = BFN
Cycle 7 SA results abnormal morphology 2%, 50 mg clomid = BFN
Cycle 8 sonogram normal 50 mg clomid + trigger = BFN
Cycle 9 SA results abnormal morphology and motility. Count 200 mill, 100mg clomid + trigger = BFN
Cycle 10 natural = BFN
Cycle 11 hsg tubes clear, natural + trigger+IUI = BFN
Cycle 12 repronex + trigger + 2 IUI = BFN
Cycle 13 natural ovaries to stimulated for more meds = BFN
Cycle 14-22 natural cycle with Acupuncture and planning ivf/icsi/DE = ALL BFN
Cycle 23 Clomid 50 mg & Progesterone = BFN
Cycle 24 Natural = BFN
Cycle 25 BCP, SA result 7% morphology = BFN
Cycle 26 BCP and Lupron preparing for IVF
Cycle 27 IVF Acupuncture, DE Retrieval April 7, Transfer April 12 =
7 eggs retrieved, 3 fertilized, 2 transferred - zero snow babies
BETA # 1 16DPO or 11dp5dt = 569
BETA # 2 19 DPO or 14dp5dt = 1078
BETA # 3 22DPO or 17dp5dt = 2414 TWINS!
BETA # 4 30DPO or 25dp5dt = 12,685 6weeks 3days 2 heartbeats! 114 & 116
Clayton and Colton Born @ 34 weeks 11/22/13
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  #4  
April 1st, 2013, 06:31 PM
smsturner's Avatar Mega Super Mommy
Join Date: Jul 2009
Location: Upstate, NY
Posts: 3,730
I would do it!! Good luck to you!
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Susan, dh Tom, dd Megan (14), ds Marcus (12), Our new baby Dean





I never knew until that moment how badly it could hurt to lose something you never really had. - Missed Miscarriage at 10 weeks - 3/26
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  #5  
April 1st, 2013, 06:46 PM
*Whiskey*'s Avatar Moving on to adoption
Join Date: Oct 2012
Location: Texas
Posts: 1,738
I would do it too. Good luck!
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"Worry is like a rocking chair, gives you something to do but never gets you anywhere"
(easier in theory than practice!)
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  #6  
April 1st, 2013, 07:42 PM
Platinum Supermommy
Join Date: Jun 2008
Location: TN
Posts: 5,592
I would say go for it too!!! Fingers crossed for you!!!! Good luck!!!!
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  #7  
April 1st, 2013, 08:02 PM
L-SBB's Avatar Bébé Cowgirl
Join Date: Sep 2008
Location: Texas
Posts: 9,810
My RE has hard rule at not more than 4 for IUI, but with your history honestly 5 vs 4 doesn't seem like a massive increase in risk for multiples so I'd go for it. good luck to you!!!
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Lara

Savannah Stylin!





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  #8  
April 1st, 2013, 09:24 PM
fromustobaby's Avatar Platinum Supermommy
Join Date: Dec 2008
Posts: 8,485
When I got pregnant with Maiya, I had 4 perfect follies for the IUI and my E2 was 1188 2 days before the IUI...I was one month from 35 at the time, and he said that he would go up to 5 follies with me because the likelihood of someone over 35 having a bunch of good eggs was low...needless to say, I only had her in there...

I also read a study about how people over 35 were not as likely to get twins from IUI for the same reason...they wouldnt let someone under 30 trigger with a number like that...

Personally, I would go for it, your E2 number is outstanding - and I have always heard that a good E2 number means good eggs...good luck!

Last edited by fromustobaby; April 1st, 2013 at 09:32 PM.
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  #9  
April 2nd, 2013, 12:58 AM
Gamer_Princess's Avatar Mega Super Mommy
Join Date: Jan 2013
Posts: 4,034
I say go for it! Good luck!
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  #10  
April 2nd, 2013, 06:06 AM
Super Mommy
Join Date: Feb 2013
Location: South Carolina
Posts: 854
I would do it!!
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  #11  
April 2nd, 2013, 09:59 AM
LindseyandJoeinAL's Avatar Mega Super Mommy
Join Date: Aug 2009
Posts: 1,612
Thank you all for the advice and well wishes! I had decided to go ahead, but I went in today for my final US and I had TEN mature follicles! They cancelled my IUI and advised me not to have sex. They offered a conversion to IVF, but their lab is under construction so we could only do the retrieval and then freeze my eggs. I don't want to waste the money on a cycle that is less than ideal, so we're just sitting out this time.

I am always the small % of random things....I was on 75 or 100 IU of Follistim for 8 days and produced all these pretty follies. Of course I did! Because that's unusual and rare.

We're going to try again next month.
__________________
Lindsey - 38
Joe - 46
TTC baby #2

lap surgery Apr 2010 stage 2 endo removed
IVF #1 BFN 11/2010
IVF #2 BFP! 12/2010
Wonderful, sweet daughter Khloe born August 2011
FET #1 - Oct 2012 BFN
FET #2 - Dec 2012 BFN
2nd lap surgery Dec 2012 stage 1 endo removed
IUI Apr 2013 cancelled due to producing 10 mature follicles
IUI June 2013 BFN
IVF #3 Sept 2013 BFN
IVF #4 Nov 2013 BFP! on 8dp3dt
Expecting boy/girl twins 8/1/14

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  #12  
April 2nd, 2013, 10:05 AM
smsturner's Avatar Mega Super Mommy
Join Date: Jul 2009
Location: Upstate, NY
Posts: 3,730
holy wow! 10!
I'm so sorry it had to be cancelled...
__________________
Susan, dh Tom, dd Megan (14), ds Marcus (12), Our new baby Dean





I never knew until that moment how badly it could hurt to lose something you never really had. - Missed Miscarriage at 10 weeks - 3/26
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  #13  
April 2nd, 2013, 10:47 AM
kayakr's Avatar Persuaded by POAS’ers
Join Date: May 2011
Location: Midwest
Posts: 3,620
Wow 10? Amazing! I still wouldn't pass this cycle up. No way. I would still Bd. I just would. Just cause you have 10 doesn't mean they are all healthy or mature or that spermies can even get to them. BD BD BD! That's still my vote!
__________________
Gretchen
Me (43) DH(33) 12 years together - ttc our first together-I have 14yr old DS
Cycles 1-6 = BFN
Cycle 7 SA results abnormal morphology 2%, 50 mg clomid = BFN
Cycle 8 sonogram normal 50 mg clomid + trigger = BFN
Cycle 9 SA results abnormal morphology and motility. Count 200 mill, 100mg clomid + trigger = BFN
Cycle 10 natural = BFN
Cycle 11 hsg tubes clear, natural + trigger+IUI = BFN
Cycle 12 repronex + trigger + 2 IUI = BFN
Cycle 13 natural ovaries to stimulated for more meds = BFN
Cycle 14-22 natural cycle with Acupuncture and planning ivf/icsi/DE = ALL BFN
Cycle 23 Clomid 50 mg & Progesterone = BFN
Cycle 24 Natural = BFN
Cycle 25 BCP, SA result 7% morphology = BFN
Cycle 26 BCP and Lupron preparing for IVF
Cycle 27 IVF Acupuncture, DE Retrieval April 7, Transfer April 12 =
7 eggs retrieved, 3 fertilized, 2 transferred - zero snow babies
BETA # 1 16DPO or 11dp5dt = 569
BETA # 2 19 DPO or 14dp5dt = 1078
BETA # 3 22DPO or 17dp5dt = 2414 TWINS!
BETA # 4 30DPO or 25dp5dt = 12,685 6weeks 3days 2 heartbeats! 114 & 116
Clayton and Colton Born @ 34 weeks 11/22/13
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  #14  
April 2nd, 2013, 11:14 AM
melissaleigh's Avatar Unashamed POASer
Join Date: Apr 2012
Posts: 1,220
Sorry it was cancelled!
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  #15  
April 2nd, 2013, 12:10 PM
Daisee37's Avatar Mega Super Mommy
Join Date: Sep 2006
Location: Twin Cities, MN
Posts: 1,974
I think it's smart to be careful. As frustrating as it is to sit out a cycle, it seems like you respond really well to meds and produce lots of eggs. Just because you're 37 doesn't mean all your eggs are bad quality, and with 10 eggs, I'd bet that several of them are good... and you probably don't want to risk quads or more! Hopefully you can be on a lower dose next time so you can trigger with just 3 or 4 follicles instead.
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  #16  
April 2nd, 2013, 12:22 PM
smsturner's Avatar Mega Super Mommy
Join Date: Jul 2009
Location: Upstate, NY
Posts: 3,730
Quote:
Originally Posted by kayakr View Post
Wow 10? Amazing! I still wouldn't pass this cycle up. No way. I would still Bd. I just would. Just cause you have 10 doesn't mean they are all healthy or mature or that spermies can even get to them. BD BD BD! That's still my vote!
Haha, I guess we live on the edge!! That would be my vote too...
kayakr likes this.
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Susan, dh Tom, dd Megan (14), ds Marcus (12), Our new baby Dean





I never knew until that moment how badly it could hurt to lose something you never really had. - Missed Miscarriage at 10 weeks - 3/26
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  #17  
April 2nd, 2013, 01:10 PM
L-SBB's Avatar Bébé Cowgirl
Join Date: Sep 2008
Location: Texas
Posts: 9,810
oh that stinks...and you definitely were a rare response to that dosage of follistim - I took 75 as well and I think I produced 2 mature and 1 maybe will catch up follie that resulted in this pregnancy. The good news is they can adjust your dosage down next cycle knowing you are such a good responder to the med and hopefully get you to a more optimal number for IUI. ((((HUGS))))
__________________
Lara

Savannah Stylin!





Remembered Forever with Love
10/13/2008 (@9w2d) 10/18/2011 (@8w5d) 2/12/2012 (@4w3d) 8/13/2012 (@10w3d)
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  #18  
April 4th, 2013, 12:34 AM
onlybygrace's Avatar Mega Super Mommy
Join Date: Aug 2012
Posts: 1,045
Wow! Thats incredible on such a low dose of FSH.
I would also hate to waste this cycle, but I think the risk of higher order multiples is too high.

If it were me, I'd consider going the IVF route and freezing them I would just hate to see 10 potential embies lost.

KUP on whatever you decide.
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Not without the grace of heaven were you born and bred - Homer, The Odyssey

TTC our 1st since June 2011

6 cycles of Clomid, 2 cycles injectables, 5 IUIs: ALL BFNs

IVF #1: Starting 5th March 2013 - Praying for my 1st ever BFP!



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  #19  
April 4th, 2013, 11:33 AM
LindseyandJoeinAL's Avatar Mega Super Mommy
Join Date: Aug 2009
Posts: 1,612
Thanks ya'll! I appreciate all your thoughts! Joe and I agreed that we simply can't risk multiples by having the IUI or plain old fashioned sex. I always fall into the tiny percentage of rare stuff, so certainly I would fall into the category of pregnant with octoplets. Then I'd be on the news and then get my own reality show and you all would tell your friends and family about "that girl" on JM who went AMA and got pregnant with a litter. And on and on and on...

I guess waiting another month or two won't kill us. We're probably going to do 1-2 more IUIs and then go back to IVF. I'll keep ya'll posted.
smsturner and kayakr like this.
__________________
Lindsey - 38
Joe - 46
TTC baby #2

lap surgery Apr 2010 stage 2 endo removed
IVF #1 BFN 11/2010
IVF #2 BFP! 12/2010
Wonderful, sweet daughter Khloe born August 2011
FET #1 - Oct 2012 BFN
FET #2 - Dec 2012 BFN
2nd lap surgery Dec 2012 stage 1 endo removed
IUI Apr 2013 cancelled due to producing 10 mature follicles
IUI June 2013 BFN
IVF #3 Sept 2013 BFN
IVF #4 Nov 2013 BFP! on 8dp3dt
Expecting boy/girl twins 8/1/14

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