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Article of the Week: Why some embryos implant and others do not


Forum: Trying to Conceive with Medical Assistance

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  #1  
September 19th, 2013, 11:03 AM
KMH KMH is offline
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Interesting article! They are working to figure out why the uterus rejects some embryos and accepts others...hopefully continued studies like this will help complete many more families.

How uterus checks embryo reveals why some do not implant
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  #2  
September 19th, 2013, 11:45 AM
plan4fate's Avatar I may bend, but not break
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Hmm... very very interesting.


A friend passed me the article this week about steroids and rpl... I'd offer to be a short term guinea pig for that study for sure.
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  #3  
September 19th, 2013, 11:57 AM
*Whiskey*'s Avatar Blessed
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Very interesting article! Definitely gives food for thought.
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  #4  
September 19th, 2013, 12:00 PM
KMH KMH is offline
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Here's the article Ashley mentioned in case anyone else is interested:

Steroids Study Gives New Hope For Women Suffering From Recurrent Miscarriage
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IVF babies Claire (4), Abigail (2) and George (2)

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  #5  
September 19th, 2013, 01:20 PM
kayakr's Avatar Persuaded by POAS’ers
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Good news that is! That is the one piece of IVF they can't seem to force - the implantation. If they can get that part narrowed down and success rates for IVF will sky rocket!
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Gretchen
Me (43) DH(33) 12 years together - ttc our first together-I have 14yr old DS
Cycles 1-6 = BFN
Cycle 7 SA results abnormal morphology 2%, 50 mg clomid = BFN
Cycle 8 sonogram normal 50 mg clomid + trigger = BFN
Cycle 9 SA results abnormal morphology and motility. Count 200 mill, 100mg clomid + trigger = BFN
Cycle 10 natural = BFN
Cycle 11 hsg tubes clear, natural + trigger+IUI = BFN
Cycle 12 repronex + trigger + 2 IUI = BFN
Cycle 13 natural ovaries to stimulated for more meds = BFN
Cycle 14-22 natural cycle with Acupuncture and planning ivf/icsi/DE = ALL BFN
Cycle 23 Clomid 50 mg & Progesterone = BFN
Cycle 24 Natural = BFN
Cycle 25 BCP, SA result 7% morphology = BFN
Cycle 26 BCP and Lupron preparing for IVF
Cycle 27 IVF Acupuncture, DE Retrieval April 7, Transfer April 12 =
7 eggs retrieved, 3 fertilized, 2 transferred - zero snow babies
BETA # 1 16DPO or 11dp5dt = 569
BETA # 2 19 DPO or 14dp5dt = 1078
BETA # 3 22DPO or 17dp5dt = 2414 TWINS!
BETA # 4 30DPO or 25dp5dt = 12,685 6weeks 3days 2 heartbeats! 114 & 116
Clayton and Colton Born @ 34 weeks 11/22/13
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  #6  
September 19th, 2013, 01:33 PM
melissaleigh's Avatar Unashamed POASer
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Things are headed in the right direction
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  #7  
September 19th, 2013, 01:53 PM
*JenJen*'s Avatar impatiently waiting
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I love when they figure out more things to help!
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  #8  
September 19th, 2013, 03:27 PM
JennyLee's Avatar TTC #1 after loss
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I love modern medicine! I have thought for awhile that our problems could be implantation related, since our eggs and sperm are all good.

I wasn't sure why I was prescribed a steroid for after transfer, but it sounds like it may have to do with the theory mentioned in the second study.
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Started stims 9/27
ER 10/8 - 24 eggs, 15 fertilized!
Blast transfer 10/13, 4 snowbabies
Very faint 10/18 (5dp5dt)
Beta #1 10/23 - 339!!!
Beta #2 10/25 - 856!!!
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Abigail arrived 6/28/14!




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  #9  
September 19th, 2013, 08:17 PM
Lucy S.'s Avatar POAS addict
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Oh interesting... Is that why?
I think that was the only med I didn't look up
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  #10  
September 20th, 2013, 05:54 AM
kayakr's Avatar Persuaded by POAS’ers
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I was giving some anti rejection medicine for my transfer but nothing with this hormone they are talking about.

Hoping they are really on to something... My only fear would be with higher success rates the price being higher too.
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Gretchen
Me (43) DH(33) 12 years together - ttc our first together-I have 14yr old DS
Cycles 1-6 = BFN
Cycle 7 SA results abnormal morphology 2%, 50 mg clomid = BFN
Cycle 8 sonogram normal 50 mg clomid + trigger = BFN
Cycle 9 SA results abnormal morphology and motility. Count 200 mill, 100mg clomid + trigger = BFN
Cycle 10 natural = BFN
Cycle 11 hsg tubes clear, natural + trigger+IUI = BFN
Cycle 12 repronex + trigger + 2 IUI = BFN
Cycle 13 natural ovaries to stimulated for more meds = BFN
Cycle 14-22 natural cycle with Acupuncture and planning ivf/icsi/DE = ALL BFN
Cycle 23 Clomid 50 mg & Progesterone = BFN
Cycle 24 Natural = BFN
Cycle 25 BCP, SA result 7% morphology = BFN
Cycle 26 BCP and Lupron preparing for IVF
Cycle 27 IVF Acupuncture, DE Retrieval April 7, Transfer April 12 =
7 eggs retrieved, 3 fertilized, 2 transferred - zero snow babies
BETA # 1 16DPO or 11dp5dt = 569
BETA # 2 19 DPO or 14dp5dt = 1078
BETA # 3 22DPO or 17dp5dt = 2414 TWINS!
BETA # 4 30DPO or 25dp5dt = 12,685 6weeks 3days 2 heartbeats! 114 & 116
Clayton and Colton Born @ 34 weeks 11/22/13
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  #11  
September 20th, 2013, 06:40 AM
Super Mommy
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what a good read ,im hoping it will help a ot of woman in the future as they seem to be finding out more and more,that can only be a good thing ,but have to agree about the price it is a gravy train of money for the doctors ,
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  #12  
September 20th, 2013, 09:46 AM
Lash's Avatar Platinum Supermommy
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Wait what is a gravy train? The meds or the procedures?
*JenJen* and KMH like this.
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  #13  
September 20th, 2013, 10:42 AM
kayakr's Avatar Persuaded by POAS’ers
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Well if they can figure out a way to produce this Trypsin Enzyme that they feel is required for implantation then the implantation rates should be higher. That is how I am reading it.
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Gretchen
Me (43) DH(33) 12 years together - ttc our first together-I have 14yr old DS
Cycles 1-6 = BFN
Cycle 7 SA results abnormal morphology 2%, 50 mg clomid = BFN
Cycle 8 sonogram normal 50 mg clomid + trigger = BFN
Cycle 9 SA results abnormal morphology and motility. Count 200 mill, 100mg clomid + trigger = BFN
Cycle 10 natural = BFN
Cycle 11 hsg tubes clear, natural + trigger+IUI = BFN
Cycle 12 repronex + trigger + 2 IUI = BFN
Cycle 13 natural ovaries to stimulated for more meds = BFN
Cycle 14-22 natural cycle with Acupuncture and planning ivf/icsi/DE = ALL BFN
Cycle 23 Clomid 50 mg & Progesterone = BFN
Cycle 24 Natural = BFN
Cycle 25 BCP, SA result 7% morphology = BFN
Cycle 26 BCP and Lupron preparing for IVF
Cycle 27 IVF Acupuncture, DE Retrieval April 7, Transfer April 12 =
7 eggs retrieved, 3 fertilized, 2 transferred - zero snow babies
BETA # 1 16DPO or 11dp5dt = 569
BETA # 2 19 DPO or 14dp5dt = 1078
BETA # 3 22DPO or 17dp5dt = 2414 TWINS!
BETA # 4 30DPO or 25dp5dt = 12,685 6weeks 3days 2 heartbeats! 114 & 116
Clayton and Colton Born @ 34 weeks 11/22/13
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  #14  
September 20th, 2013, 11:15 AM
Lash's Avatar Platinum Supermommy
Join Date: Jun 2006
Location: North Texas
Posts: 17,679
I just can't figure out what Vicky is meaning about the gravy train part.
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  #15  
September 20th, 2013, 03:05 PM
JennyLee's Avatar TTC #1 after loss
Join Date: Feb 2011
Posts: 3,112
All this research costs money...
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TTC #1 since 1/11, Unexplained Infertility
M/C 2/12
Polyp Removal 11/12
4 failed IUIs

IVF #1
Started stims 9/27
ER 10/8 - 24 eggs, 15 fertilized!
Blast transfer 10/13, 4 snowbabies
Very faint 10/18 (5dp5dt)
Beta #1 10/23 - 339!!!
Beta #2 10/25 - 856!!!
U/S 11/14 - Heart rate 144!

Abigail arrived 6/28/14!




My Belly Pics
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  #16  
September 20th, 2013, 03:29 PM
ChiChica's Avatar Mega Super Mommy
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Location: Chicago
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Neat! Maybe they can at least develop a method for determining which embryos are releasing trypsin as a way to choose which embryos to transfer. That would be a good first step!
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  #17  
September 20th, 2013, 05:58 PM
Gamer_Princess's Avatar Mega Super Mommy
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I think Vicky is referring to the gravy train being what Gretchen mentioned... with more success rates.. the cost would most likely increase...
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  #18  
September 20th, 2013, 06:54 PM
KMH KMH is offline
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So you wouldn't be willing to pay more for a higher success rate? Researchers and scientists shouldn't be compensated for these revolutionary discoveries/medicines? I get annoyed at the cost of IVF sometimes, but my RE, embryologist, and nurses worked hard and gave up holidays and weekends to give me a family...they deserve to be well-paid!
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  #19  
September 20th, 2013, 07:35 PM
Gamer_Princess's Avatar Mega Super Mommy
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I was just trying to help clarify the gravy train reference well what I thought she meant Honestly I would pay as much as it took to complete my family so was not trying to step on toes...Sorry was just trying to help....
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  #20  
September 20th, 2013, 08:43 PM
KMH KMH is offline
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Quote:
Originally Posted by Gamer_Princess View Post
so was not trying to step on toes...Sorry was just trying to help....
Sorry if what I said sounded harsh...I wasn't directing it all at you. Just wanted to give kudos to the researchers, drs, ect. who help us!
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