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An endometrial biopsy is a procedure to remove a small sample of the lining of the uterus (endometrium). The sample is examined under a microscope for abnormal cells. An endometrial biopsy helps a health professional evaluate whether the endometrium is going through its normal stages of change during the menstrual cycle and to determine whether cancerous conditions are present.
This procedure can cause a lot of discomfort. My RE suggested that I take an anti-inflamatory (Aleve) and a pain killer (Tylenol) about an hour before the procedure. I'm so glad I did. I have a high pain tolerance but it was still a little uncomfortable. It feels like AF cramps for a moment and then it's gone, but you tend to spot for a day or so after.
It's recommended to NOT TTC the cycle that you have this done because it can cause m/c. It's usually done around 7dpo and it's used to determine the condition of the lining and which can indicate progesterone issues if the lining isn't thick enough.