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Male Contraceptive Pill

Forum: Birth Control


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August 21st, 2006, 09:46 AM
mommytutu's Avatar mom to Emma & Jacqueline
Join Date: Oct 2005
Location: Bradenton, Fl
Posts: 13,831
Here are three articles that I have found relating to male contraception. It's interesting, to say the least, and if it is approved it could prove to be quite beneficial in preventing unwanted pregnancies - not to mention it gives men more control over their sexual health. There would be no more "She tricked my son into bed so she could get knocked up!"

Reversible Male Contraceptive Pill, Androgen Or Androgen-progestagen Treatment Combinations
29 Apr 2006

According to a study carried out at the ANZAC Research Institute, Sydney, Australia, a hormonal contraceptive pill that stops men from producing sperm, allows normal sperm production three to four months after treatment is ceased.

You can read about this study in The Lancet.

Sperm production in men can be inhibited by androgen or androgen-progestagen treatment combinations, just as hormone treatment in women can suppress ovulation.

Researchers monitored 1,500 men between 1990-2005. They were aged 18-51. On average, it took the men 3.4 months, after ceasing treatment, to be able to produce sperm normally again. Those who recovered sperm production faster were older men, men of Asian origin, those with a higher initial sperm count before treatment and those who had treatment for a short time.

Currently, a large phase III study with an androgen treatment is underway in China. A large, multicentre phase II study of androgen-progestagen combinations is being completed in Europe.

To date, the only form of contraception available to men are condoms and vasectomy. The problem with a vasectomy is that it can often be a permanent procedure - the man cannot reverse it. There have also been many cases of vasectomies not being 100% effective. Condoms are not 100% effective. Another method available to men is withdrawal - the least reliable contraception method.

Dr Peter Liu, Head Researcher, said “Our data provide strong assurance that the previously described efficacy of hormonal male contraceptives is coupled with highly predictable recovery to semen characteristics that are compatible with fertility. These findings thereby increase the promise of new contraceptive drugs allowing men to share more fairly the satisfaction and burden of family planning.”

Dr. Peter Liu is from the Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, USA. He is located at the ANZAC Research Institute, University of Sydney, Australia.

-- ANZAC Research Institute
-- http://www.thelancet.com

Written by: Christian Nordqvist
Editor: Medical News Today
Article URL: http://www.medicalnewstoday.com/heal...p?newsid=42504[/b]

The male contraceptive pill
Dr Trisha Macnair

There's a whole gamut of pills and devices to help women control their fertility, so what's being done to give the boys a bit more choice? One possibility is a pill.

Men's choices
At the moment about all that's available to men in the way of contraception is either the condom or the more drastic step of vasectomy. The third option is the rather unpopular technique of abstinence - it's never been a favourite among my male patients! But it has its advantages - see, for example, this safer sex website.

For lots of information about every sort of contraceptive issue see the International Planned Parenthood Federation.

The contraceptive pill revolutionised life for women in the 1960s and is now used by millions of women around the world. But what about a pill for men? The answer is that plenty of researchers are racing to develop a male pill (it's a potentially lucrative business) but so far there's nothing like it in general use.

Hormone treatments

Early attempts to develop a male pill were based on using testosterone

Most of the early attempts to develop a male pill were based on using testosterone to trick the brain into turning off sperm production. But this has not been as successful as the female pill has been in switching off ovulation. Results have been a bit hit-or-miss, and this approach has proved ineffective in as many as one in five men.

More recent research has been based on the finding that another hormone also controls sperm production. This hormone is prolactin - familiar to women because it controls the production of breast milk, but also produced by men. To act as a contraceptive, tablets that inhibit the production of prolactin must be taken every day along with injections or implants of testosterone - quite a commitment for young men, who are notoriously less reliable than women in taking medication.

Injections and patches
Other combinations have also been looked at, such as weekly injections of testosterone and daily progestogen pills. It may be possible to give the testosterone component using a skin patch instead of an injection.

Research in Manchester has combined desogestrel (also used in female contraceptives) and patches of testosterone. The desogestrel stops the production of testosterone in the testes, so stopping sperm production, while the testosterone patch provides the needed testosterone to the rest of the body (without this men would lose their facial hair and could develop breasts). But scientists have been struggling to make this work in every man who takes the hormone combination rather than just about 60 per cent of them.

Side effects
Side effects have been a particular problem

All drugs have some potential side effects. Side effects have been a particular problem for hormone-based male contraceptives. It's hoped that by combining hormones, side effects of testosterone such as prostate problems, nausea, jaundice and headaches may be reduced.

Another problem is ensuring the effect is temporary or reversible.

A different approach
New research is looking for a different way to stop sperm production. Some work that's proving promising but is still in its very early stages is looking at how to disrupt protein signals between the cells that make sperm. Another technique under scrutiny stops sperm being ejaculated out of the testis. These are just two of many techniques being studied.

Would men want to take a pill?
Many women, used to bearing the brunt of decisions about contraception, may be a bit cynical about men's interest in taking a contraceptive pill.

But in a recent international survey two-thirds of men questioned said they would use the pill if it were available - and nearly all women trusted their partners to take it. Even in Hong Kong, the most conservative area of the study, nearly half of the men said they would use it.

How far off is the male pill?
The biggest problem facing scientists at the moment is developing a male contraceptive that can be expected to work in every man all of the time. It's not good enough to reduce sperm counts from the normal levels of several million down to just a few - one sperm is all that's needed to create a new life.

Shortage of takers
A recent trial of the combination male contraceptive in the UK ran into problems when they couldn't find enough men to volunteer.

In 2003 researchers in Australia did a limited trial of a combination contraceptive that showed it was 100 per cent effective and free of unacceptable side effects. Importantly, it was also reversible - normal fertility levels returned within a few months of stopping the treatment. The word ‘pill' is a misnomer as this form of contraceptive combines a testosterone implant and a three-monthly injection of progestin, a hormone used in female contraceptive pills.

However, it's likely to be a long time before this treatment comes out of the research lab and into the chemists.

It's been estimated that there will be a commercially available male pill within the next few years. Mind you, people were saying that ten years ago! Right now there's nothing anywhere near as simple as the pill for women.

This article was last medically reviewed by Dr Rob Hicks in May 2005.

A British study finds that male contraceptive pills appear to be a safe and effective means of birth control.
April 29, 2006

A trial involving 1,500 men found that sperm levels recovered within a little more than three months of going off the pill, Sky News reported. The findings were published in the journal The Lancet.

"These findings thereby increase the promise of new contraceptive drugs allowing men to share more fairly the satisfaction and burden of family planning," Peter Liu of the University of Sydney said.

Fred Wu of the University of Manchester told the Daily Mail he expects a pill for men to be on the market within five to eight years.

Copyright 2006 by United Press International

Kayttie, in love with Shane, mom to Emma Brynn and Jacqueline Noel

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